Objective SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the ...
The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double-blind ...
Cedars-Sinai investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. Science X ...
A first-in-human clinical trial evaluating an investigational gene therapy targeting complement-mediated pathways in ...
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